South Africa is the last place on earth Quaaludes can still be found; Hamilton travels there to study the drug and learns of a dark history of medical experimentation.
From the heavenly cloud forests of Oaxaca to a viral video of Miley Cyrus, Hamilton investigates the inconspicuous yet extraordinary psychedelic plant Salvia divinorum.
Hamilton embarks on an aquatic adventure to Reunion Island and Madagascar to investigate ichthyoallyeinotoxism and a twisted history of hallucinogenic fish.
From the greenhouses of Thai cactophiles to the Tamaulipan thornscrub, Hamilton traces the history of peyote with the help of a Native American peyotist.
Hamilton heads to India to see industrial Ketamine synthesis, and speak with therapists and luminaries in an attempt to understand the role of dissociative anesthetics in society.
Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers the chemistry behind a mushroom-inspired pharmaceutical.
Deep in the Andean highlands of Peru, Hamilton becomes the apprentice of a local shaman, learning how to use the night-blooming San Pedro cactus as a medicine.
Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin of an international toad venom smoking phenomenon.
From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs in order to understand the process behind a great American folk art.
After revealing a scientific mystery around Tramadol-addicted cows in Central Africa, Hamilton follows a Gabonese opiate addict to a psychedelic ritual.
With the precise structure of LSD's molecular target identified, Hamilton discusses the new era of psychedelic research and meets pioneers of the field.
